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Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor β1.

Jack S LawsonH M SymeC P D Wheeler-JonesJ Elliott
Published in: BMC veterinary research (2018)
FCF and CKD-FCF can be cultured via a simple method and represent a model for the investigation of the progression of fibrosis in feline CKD. The findings of this study suggest TGF-β1 may be involved in fibroblast-myofibroblast transition in feline CKD, as in other species.
Keyphrases
  • transforming growth factor
  • chronic kidney disease
  • epithelial mesenchymal transition
  • endothelial cells
  • transcription factor
  • wound healing
  • oxidative stress
  • heat shock protein