New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss.

Neil JohnsCynthia StretchBenjamin H L TanTora S SolheimSveinung SørhaugNathan A StephensIoannis GioulbasanisRichard J E SkipworthD A Christopher DeansAntonio ViganoJames A RossOliver F BatheMichel L TremblayStein KaasaFlorian StrasserBruno GagnonVickie E BaracosSambasivarao DamarajuKenneth C H Fearon

Published in: Journal of cachexia, sarcopenia and muscle (2016)

The rs1799964 in the TNF gene and rs4291 in the ACE gene are new associations when the definition of cachexia is based on a combination of WL and LSMI. These findings focus attention on pro-inflammatory cytokines and the renin-angiotensin system as biomarkers/mediators of muscle wasting in cachexia.

Keyphrases

skeletal muscle
genome wide
copy number
weight loss
dna methylation
rheumatoid arthritis
papillary thyroid
bariatric surgery
insulin resistance
working memory
genome wide identification
angiotensin converting enzyme
metabolic syndrome
gastric bypass
anti inflammatory
body mass index
young adults