Long-Term Follow-Up of the LEAP Study: Early Versus Delayed Levodopa in Early Parkinson's Disease.

Henrieke L FrequinConstant V M VerschuurSven R SuwijnJudith A BoelBart PostBastiaan R BloemJohannes J van HiltenTeus van LaarGerrit TissinghAlexander G MuntsJoke M DijkAnthony E LangMarcel G W DijkgraafJeroen HooglandRob M A de Bienull null

Published in: Movement disorders : official journal of the Movement Disorder Society (2024)

We did not find a difference in disease progression or in prevalence of motor complications between patients with early PD starting treatment with a low dose of levodopa 40 weeks earlier versus 40 weeks later over the subsequent 5 years. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

low dose
risk factors
parkinson disease
deep brain stimulation
high dose
replacement therapy
smoking cessation