Non-Invasive Drug Delivery across the Blood-Brain Barrier: A Prospective Analysis.
Sarfaraz K NiaziPublished in: Pharmaceutics (2023)
Non-invasive drug delivery across the blood-brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is a tightly packed layer of endothelial cells that shields the brain from harmful substances in the blood, allowing necessary nutrients to pass through. It is a highly selective barrier, which poses a challenge to delivering therapeutic agents into the brain. Several non-invasive procedures and devices have been developed or are currently being investigated to enhance drug delivery across the BBB. This paper presents a review and a prospective analysis of the art and science that address pharmacology, technology, delivery systems, regulatory approval, ethical concerns, and future possibilities.
Keyphrases
- drug delivery
- blood brain barrier
- cerebral ischemia
- cancer therapy
- endothelial cells
- resting state
- white matter
- drug release
- public health
- functional connectivity
- transcription factor
- hiv infected
- heavy metals
- multiple sclerosis
- atomic force microscopy
- high resolution
- decision making
- brain injury
- risk assessment
- vascular endothelial growth factor
- subarachnoid hemorrhage