Letter to the Editor: Sodium-Glucose Cotransporter-2 Inhibitors Are Not the Magic Pills for Control of Ascites in Cirrhosis and Diabetes.

We read with great interest the case series by Gordon et al. It is indeed very interesting to know that sodium-glucose cotransporter-2 inhibitors (SGLT2-I) can improve ascites control and pedal edema along with achieving adequate glycemic control in patients with cirrhosis and type 2 diabetes mellitus(T2DM) (1). But there are certain concerns which we would like highlight. SGLT2-I prevent sodium and glucose reabsorption in proximal convoluted tubule (PCT) of kidneys which is similar to loop diuretics. Attributing ascites control to SGLT2-I in patients who were intolerant to diuretics seems unusual. As mentioned by the authors, urinary sodium level has to be assessed in future studies.