The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS.
Melanie N HurstConnor J BeeboutAlexis HollingsworthKirsten R GuckesAlexandria PurcellTomas A BermudezDiamond WilliamsSeth A ReasonerM Stephen TrentMaria HadjifrangiskouPublished in: bioRxiv : the preprint server for biology (2023)
in the absence of PmrA. Finally, we show that QseB controls glutamate metabolism during the antibiotic response. These results suggest that rewiring of QseB-mediated metabolic genes can lead to stable antibiotic resistance in subpopulations within the host, thereby contributing to antibiotic treatment failure.