Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice.

Young Eun KimHyung Chul ChoiGaewon NamBu Young Choi

Published in: Journal of cosmetic dermatology (2018)

Our results illustrate that COS promotes hair growth in vitro and in vivo by regulating the amount of growth factors and/or the activity of cellular responses through coordination of the WNT-β-catenin, hedgehog-Gli, and TGF-β1-Smad pathways.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
induced apoptosis
cell proliferation
endothelial cells
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
induced pluripotent stem cells
cell death