How to approach pancreatic cancer after neoadjuvant treatment: assessment of resectability using multidetector CT and tumor markers.
Sun Kyung JeonJeong Min LeeEun Sun LeeMi Hye YuIjin JooJeong Hee YoonJin-Young JangKyoung Bun LeeSang Hyup LeePublished in: European radiology (2021)
• R0 resection rates following neoadjuvant chemotherapy ± radiation therapy (CRT) were 82.8%, 70.1%, and 18.5% in resectable, borderline resectable, and locally advanced disease, respectively, at post-CRT CT (p < 0.001). • For post-CRT borderline resectable disease, ≥ 50% decrease in carbohydrate antigen (CA) 19-9 was significantly associated with R0 resection. • For post-CRT locally advanced disease, small post-CRT tumor size ≤ 2 cm and decreased tumor-arterial contact were significantly associated with R0 resection.
Keyphrases
- locally advanced
- neoadjuvant chemotherapy
- radiation therapy
- rectal cancer
- squamous cell carcinoma
- cardiac resynchronization therapy
- phase ii study
- computed tomography
- sentinel lymph node
- heart failure
- radiation induced
- image quality
- magnetic resonance imaging
- clinical trial
- positron emission tomography
- early stage
- clinical evaluation
- pet ct