Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer.

Zhaoji PanHao LinYanyan FuFanpeng ZengFeng GuGuoping NiuJian FangBing Gu

Published in: Frontiers in immunology (2023)

Study results show the involvement of hub genes like CCL3, MMP3, and TIMP1 in the pathogenesis of UC. These genes could serve as a novel pharmacological regulator of UC. These could be used as a therapeutic target for treating patients with UC and may serve as biomarkers for immune cell infiltration in colon cancer.

Keyphrases

bioinformatics analysis
genome wide
genome wide identification
ulcerative colitis
dna methylation
transcription factor
genome wide analysis
copy number
gene expression