Adeno-associated virus-9 reverses delayed gastric emptying of solids in diabetic mice.

Xiaojie LiSihan JiGianluca CiprianiMatthew L HillestadSeth T EisenmanMichael A BarryKarl A NathDavid R LindenAlec WrightShefaa AlAsfoorMadhusudan GroverLei ShaLinda C HsiGianrico Farrugia

Published in: Neurogastroenterology and motility (2023)

Injection of scAAV9 into diabetic C57BL6 mice produced a biological response that resulted in acceleration of GE independently of the cargo delivered by the AAV9 vector. Further research is needed to determine whether use of AAV mediated gene transduction in the gastric muscularis propria is beneficial and warranted.

Keyphrases

gene therapy
type diabetes
high fat diet induced
copy number
genome wide
wound healing
gene expression
genome wide identification
metabolic syndrome
dna methylation
skeletal muscle