A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2.

Yujie LiYongfeng SongMeng ZhaoYanjing GuoChunxiao YuWenbin ChenShanshan ShaoChao XuXinli ZhouLifang ZhaoZhenhai ZhangTao BoYu XiaChristopher G ProudXuemin WangLi WangJiajun ZhaoLing Gao

Published in: Hepatology (Baltimore, Md.) (2017)

CRTC2 regulates the transcription of SREBP-2 by interfering with the recognition of insulin response element 1 in the SREBP-2 promoter by forkhead box O1, thus inducing SREBP-2/HMGCR signaling and subsequently facilitating hepatic cholesterol synthesis. (Hepatology 2017;66:481-497).

Keyphrases

transcription factor
type diabetes
low density lipoprotein
gene expression
metabolic syndrome
insulin resistance
weight loss