Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance.

Lili ZhengJunqiu JiaYan ChenRenyuan LiuRunjing CaoManlin DuanMeijuan Zhang Yun Xu

Published in: Journal of neuroinflammation (2022)

Collectively, our results demonstrated that PTX showed therapeutic potentials in VAD and alleviated ischemic white matter injury via modulating Mertk-mediated myelin clearance in microglia.

Keyphrases

white matter
multiple sclerosis
ischemia reperfusion injury
inflammatory response
signaling pathway
cerebral ischemia
neuropathic pain
mouse model
spinal cord
oxidative stress
spinal cord injury
blood brain barrier