Non-invasive assessment of coronary endothelial function in children and adolescents with type 1 diabetes mellitus using isometric handgrip exercise-MRI: A feasibility study.
Gaëtan ZwingliJérôme YerlyYvan MivelazSophie Stoppa-VaucherAndrew A DwyerNelly PitteloudMatthias StuberMichael HauschildPublished in: PloS one (2020)
Our pilot study demonstrates the feasibility of using a totally non-invasive IHE-MRI technique in children and adolescents with and without T1DM. Preliminary results suggest a blunted endothelium-dependent coronary vasomotor function in children with T1DM (>5 years). Better knowledge and new methodologies may improve surveillance and care for T1DM patients to reduce cardiovascular morbidity and mortality.
Keyphrases
- healthcare
- coronary artery disease
- end stage renal disease
- coronary artery
- magnetic resonance imaging
- contrast enhanced
- ejection fraction
- chronic kidney disease
- newly diagnosed
- public health
- young adults
- palliative care
- prognostic factors
- heart failure
- physical activity
- nitric oxide
- aortic stenosis
- diffusion weighted imaging
- high intensity
- magnetic resonance
- adipose tissue
- atrial fibrillation
- skeletal muscle