At any level of adiposity, relatively elevated leptin concentrations are associated with decreased insulin sensitivity.

Martina Chiriacò Lorenzo Nesti Allan Flyvbjerg Alain Golay Julie-Anne Nazare Christian Heinz Anderwald Asimina Mitrakou Roberto Bizzotto Andrea Mari Andrea Natali

Published in: The Journal of clinical endocrinology and metabolism (2023)

Subjects with leptin levels that are inappropriately elevated for their fat mass show whole-body/adipose tissue insulin resistance and hyperinsulinemia, regardless of BMI.

Keyphrases

insulin resistance
adipose tissue
high fat diet
polycystic ovary syndrome
metabolic syndrome
high fat diet induced
body mass index
skeletal muscle
type diabetes
weight gain
glycemic control