Cross-sectional study of population-specific streptococcal antibody titres in Uganda.
Emmy OkelloMeghna MuraliJoselyn RwebemberaJenifer AtalaAsha C BowenNada HarikGloria KaudhaSamalie KitoolekoChris LongeneckerEmma NdagireIsaac Otim OmaraLinda Mary OyellaTom ParksJafesi PulleCraig SableRachel SarnackiElizabeth SteinMeghan ZimmermanNicholas de KlerkJonathan CarapetisAndrea Zawacki BeatonPublished in: Archives of disease in childhood (2020)
The estimated Ugandan paediatric population standardised 80% upper-limit-of-normal ASO and ADB titres is higher than many global populations. Appropriateness of using population-specific antibody cutoffs is yet to be determined and has important implications for the sensitivity and specificity of rheumatic fever diagnosis.
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