MiR-200c-3p as a novel genetic marker and therapeutic tool for alopecia areata.

Ahmed Ibrahim AbdElneam Mohammed Saleh Al-Dhubaibi Saleh Salem Bahaj Ghadah I ALHetheli

Published in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2024)

We were able to identify the influence of miR-200c-3p on both PLCG1 and RPS6KP1 genes which in turn regulate the EGFR tyrosine kinases resistance pathway that displayed the most substantial increase in activity. Our outcomes shed light on the era of the potential theranostic role of this innovative miRNA in AA.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
genome wide
small cell lung cancer
photodynamic therapy
tyrosine kinase
sensitive detection
fluorescent probe
living cells
copy number
metabolic syndrome
risk assessment
climate change
gene expression
human health
skeletal muscle