Efficacy of Omadacycline or Vancomycin Combined with Germinants for Preventing Clostridioides difficile Relapse in a Murine Model.
Noah D BudiJared J GodfreyNasia SafdarSanjay K ShuklaWarren E RosePublished in: The Journal of infectious diseases (2022)
In murine models of CDI, omadacycline improved survival versus vancomycin. Germinant-antibiotic combinations were more effective at preventing rCDI compared to antibiotics alone without inducing toxin production.