Enhanced synergistic antitumor effect of a DNA vaccine with anticancer cytokine, MDA-7/IL-24, and immune checkpoint blockade.

Seyed Mohammad MiriBehzad PourhosseinSeyed Younes HosseiniMohsen KeshavarzShohreh ShahmahmoodiMohammad Reza ZolfaghariSeyed Reza MohebbiAli GorjiAmir Ghaemi

Published in: Virology journal (2022)

The synergy between the E7 DNA vaccine and MDA-7/IL-24 suggests that DNA vaccines' low immunogenicity can be effectively addressed by coupling them with an immunoregulatory agent. Moreover, IL-10 blockade can be considered a complementary treatment to improve the outcome of conventional or novel cancer therapies.

Keyphrases

circulating tumor
cell free
single molecule
breast cancer cells
papillary thyroid
cell cycle arrest
squamous cell
cell proliferation
cell death
signaling pathway
pi k akt