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The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study.

Yuhao SunShuai YuanXuejie ChenJing SunRahul KallaLili YuLijuan WangXuan ZhouXiangxing KongTherese HeskethGwo-Tzer HoKefeng DingMalcolm DunlopSusanna C LarssonJack SatsangiTherese HeskethXiaoyan WangXue LiEvropi TheodoratouEdward L Giovannucci
Published in: The American journal of gastroenterology (2023)
Genetic and lifestyle factors were independently associated with susceptibility to incident CD and UC. Adherence to a favorable lifestyle was associated with a nearly 50% lower risk of CD and UC among participants at a high genetic risk.
Keyphrases
  • cardiovascular disease
  • metabolic syndrome
  • genome wide
  • weight loss
  • physical activity
  • copy number
  • type diabetes
  • gene expression
  • adipose tissue
  • nk cells
  • insulin resistance
  • ulcerative colitis
  • breast cancer risk