Postoperative chemotherapy improves survival in patients with resected high-risk Stage II colorectal cancer: results of a systematic review and meta-analysis.
Constantinos SimillisH K S I SinghT AfxentiouS MillsO J WarrenJ J SmithP RiddleM AdaminaD CunninghamP P TekkisPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2020)
Adjuvant chemotherapy in high-risk Stage II colorectal cancer results in a modest survival improvement and should be considered on an individual patient basis. Due to potential heterogeneity and selection bias of the included studies, and lack of separate rectal cancer data, further large randomized trials with predefined inclusion criteria and standardized chemotherapy regimens are required.