Intestinal inflammations increase efflux of innate lymphoid cells from the intestinal mucosa to the mesenteric lymph nodes through lymph-collecting ducts.
Kazuki HoriuchiMasaaki HigashiyamaChie KuriharaKouji MatsumuraRina TanemotoSuguru ItoAkinori MizoguchiShin NishiiAkinori WadaKenichi InabaNao SugiharaYoshinori HanawaNaoki ShibuyaYoshikiyo OkadaChikako WatanabeShunsuke KomotoKengo TomitaRyota HokariPublished in: Microcirculation (New York, N.Y. : 1994) (2021)
Intestinal ILCs were found to migrate through MLVs. The altered mobilization of MLV-ILCs after stimuli suggests that ILCs play an important role in regulating the immune responses at the secondary lymph nodes.