Successful Mesenchymal Stem Cell Application in Supraventricular Tachycardia-Related Necrotizing Enterocolitis: A Case Report.
Hasan AkdumanDilek DilliErgun ErgünEmin ÇakmakçıSerpil Kaya ÇelebiRumeysa ÇitliAyşegül ZenciroğluPublished in: Fetal and pediatric pathology (2019)
Necrotizing enterocolitis (NEC) is one of the most important life- threatening diseases in neonates. Recurrent episodes of supraventricular tachycardia (SVT) can lead to gut ischemia, with subsequent reperfusion injury resulting in NEC. Mesenchymal stem cells (MSCs) are multi-potential cells which can differentiate into multiple cell types. Case report: A 22-day old male baby delivered to 34 yr old mother at 37-weeks' gestation via cesarean section, birth weight 3550 g, developed NEC 14 hours after being treated with cardioversion for SVT. At laparotomy, there was pan-NEC, and 60 cm of necrotic and perforated bowel was resected. 1 × 107 umbilical cord origin allogeneic MSCs were given intravenously, with subsequent improvement of the remaining bowel. Conclusion: MSC may be a promising treatment for adjacent ischemic bowel in NEC helping prevent short bowel syndrome.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- catheter ablation
- gestational age
- birth weight
- bone marrow
- case report
- cell therapy
- low birth weight
- atrial fibrillation
- induced apoptosis
- preterm infants
- weight gain
- preterm birth
- cerebral ischemia
- oxidative stress
- lymph node
- cell cycle arrest
- cell death
- stem cells
- endoplasmic reticulum stress
- signaling pathway
- human health
- acute ischemic stroke
- high dose
- climate change
- coronary artery disease
- replacement therapy
- blood brain barrier
- body mass index
- smoking cessation
- ischemia reperfusion injury
- weight loss