Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging.
Irene M VavasourPeng SunCarina GrafJackie T YikShannon H KolindDavid Kb LiRoger TamAna-Luiza SayaoAlice SchabasVirginia DevonshireRobert CarruthersAnthony TraboulseeGr Wayne MooreSheng-Kwei SongCornelia LaulePublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)
Relaxation and DBSI-derived MRI measures show differences between MS subtypes related to the severity and composition of underlying tissue damage. RRMS showed oedema, demyelination and axonal loss compared with CIS. Progressive MS had even more evidence of increased oedema, demyelination and axonal loss compared with CIS and RRMS.
Keyphrases
- multiple sclerosis
- spinal cord injury
- white matter
- single molecule
- high resolution
- mass spectrometry
- magnetic resonance imaging
- contrast enhanced
- oxidative stress
- traumatic brain injury
- lipopolysaccharide induced
- ms ms
- optic nerve
- lps induced
- cognitive impairment
- computed tomography
- inflammatory response
- cerebral ischemia
- brain injury
- fluorescence imaging