SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension.
Christine VeithIpek Vartürk-ÖzcanMagdalena WujakStefan HadzicCheng-Yu WuFenja KnoeppSimone KrautAleksandar PetrovicMarija GredicOleg PakMonika BrosienMarie HeimbrodtJochen WilhelmFriederike C WeiselKathrin MalkmusKatharina SchäferHenning GallKhodr TelloDjuro KosanovicAkylbek SydykovAkpay SarybaevAndreas GüntherRalf P BrandesHorst-Walter BirkFriedrich GrimmingerHossein Ardeschir GhofraniRalph T SchermulyGrazyna KwapiszewskaNatascha SommerNorbert WeissmannPublished in: Circulation (2022)
This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.