Soluble CD146 in the detection and grading of intravascular and tissue congestion in patients with acute dyspnoea: analysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort.

Renata JuknevičienėJustas SimonavičiusAurimas MikalauskasKamilė Čerlinskaitė-BajorėMattia ArrigoVytautas JuknevičiusIrina Alitoit-MarroteDenis KablučkoLoreta BagdonaitėDalius VitkusMindaugas BalčiūnasGitana ZuozienėJūratė BarysienėDiana ŽaliaduonytėKęstutis StašaitisAušra KavoliūnienėAlexandre MebazaaJelena Čelutkienė

Published in: BMJ open (2022)

sCD146 concentration reflects the degree of intravascular and tissue congestion assessed by clinical and echocardiographic indices, with this association maintained in patients with low NT-proBNP. Our data support the notion that NT-proBNP might represent heart stretch while sCD146 rather represents peripheral venous congestion.

Keyphrases

left ventricular
coronary artery
pulmonary hypertension
liver failure
heart failure
computed tomography
mitral valve
electronic health record
big data
drug induced
loop mediated isothermal amplification
machine learning
artificial intelligence
quantum dots
data analysis