Nobiletin Alleviated Epithelial-Mesenchymal Transition of Hepatocytes in Liver Fibrosis Based on Autophagy-Hippo/YAP Pathway.

Yuting HaoDongliang FengHuarui YeTian-Tian Zhang

Published in: Molecular nutrition & food research (2023)

Therefore, this study provides evidences that NOB can protect hepatocytes from undergoing EMT during liver fibrosis by inducing autophagy and subsequently modulating the Hippo/YAP pathway.

Keyphrases

liver fibrosis
epithelial mesenchymal transition
signaling pathway
cell death
endoplasmic reticulum stress
transforming growth factor
oxidative stress
liver injury
drug induced