Synthesis and biological profile of substituted benzimidazoles.

Neelam VashistSurinder Singh SambiBalasubramanian NarasimhanSanjiv KumarSiong Meng LimSyed Adnan Ali ShahKalavathy RamasamyVasudevan Mani

Published in: Chemistry Central journal (2018)

Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their IC50 values were more potent than 5-fluorouracil.

Keyphrases

staphylococcus aureus
microbial community
candida albicans
molecular docking
single cell
genetic diversity
molecular dynamics simulations