Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier.

Hsuan-Ju LaiHa T DoanElliot Y LinYi-Ling ChiuYuan-Kai ChengYi-He LinHao-Sen Chiang

Published in: Inflammatory bowel diseases (2023)

PAD4-mediated NET formation has a detrimental role in acute colitis. NET-associated histones directly inhibit intestinal barrier function, resulting in cytotoxicity in vitro and in vivo.

Keyphrases

liver failure
respiratory failure
endothelial cells
drug induced
aortic dissection
ulcerative colitis
intensive care unit
hepatitis b virus
mechanical ventilation