Prospective Evaluation of High Titer Autoantibodies and Fetal Home Monitoring in the Detection of Atrioventricular Block Among Anti-SSA/Ro Pregnancies.
Jill P BuyonMala MassonCaroline G IzmirlyColin PhoonRuben AchermanElena SinkovskayaAlfred AbuhamadMajd MakhoulGary SatouWhitnee HoganNelangi PintoAnita Moon-GradyLisa HowleyMary DonofrioAnita KrishnanHoma AhmadziaStephanie LevasseurErin PaulSonal OwensKristopher CumbermackJyothi MattaGary JoffeChristopher LindbladeCaitlin HaxelKatherine KohariJoshua CopelJames StrainicTam DoanKarla Bermudez-WagnerConisha HollomanShreya S ShethStacy KillenTheresa TacyMichelle KaplinskiLisa HornbergerPhilip M CarlucciPeter IzmirlyNicola FraserRobert M ClancyBettina F CuneoPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
High-titer antibodies are associated with an increased incidence of AVB. Anti-SSA/Ro titers remain stable over time and do not explain the discordant recurrence rates, suggesting that other factors are required. Fetal heart rate and rhythm (FHRM) with results confirmed by a pediatric cardiologist reliably detects conduction abnormalities, which may reduce the need for serial echocardiograms.