Inflammatory plasma profile in genetic symptomatic and presymptomatic Frontotemporal Dementia - A GENFI study.
Chiara FenoglioMaria SerpenteMarina ArcaroTiziana CarandiniLuca SacchiManuela PintusEmanuela RotondoVittoria BorracciLaura GhezziArabella BouziguesLucy L RussellPhoebe H FosterEve Ferry-BolderJohn C van SwietenLize C JiskootHarro SeelaarRaquel Sánchez ValleRobert LaforceCaroline GraffRik VandenbergheAlexandre de MendonçaPietro TiraboschiIsabel SantanaAlexander GerhardJohannes LevinSandro SorbiMarkus OttoFlorence PasquierSimon DucharmeChris R ButlerIsabelle Le BerElizabeth FingerMaria Carmela TartagliaMario MasellisJames B RoweMatthis SynofzikFermin MorenoBarbara BorroniJonathan D RohrerAndrea ArighiDaniela Galimbertinull nullPublished in: Brain, behavior, and immunity (2024)
We showed that inflammatory proteins are upregulated in MAPT and GRN SMC, with some specific factors altered in GRN only, whereas no changes were seen in C9ORF72 carriers. Notably, only IL-1α levels were decreased in both SMC and PMC, independent of the type of causal mutation, suggesting common modifications occurring in the preclinical phase of the disease.