Sex-specific loss of mitochondrial membrane integrity and mass in the auditory brainstem of a mouse model of Fragile X syndrome.

Claire CaronElizabeth A McCullagh Giulia Bertolin

Published in: bioRxiv : the preprint server for biology (2024)

There are sex differences in mitochondrial structures in the MNTB.FXS female mice have disordered mitochondria that are also longer and less branched than wildtype females.Male FXS mice have fewer overall mitochondria compared to males.

Keyphrases

mouse model
oxidative stress
high fat diet induced
cell death
reactive oxygen species
endoplasmic reticulum
high resolution
case report
wild type
mass spectrometry
adipose tissue
hearing loss