Evaluation of Brain Nuclear Medicine Imaging Tracers in a Murine Model of Sepsis-Associated Encephalopathy.
Dávid SzöllősiNikolett HegedűsDániel S VeresIldikó FutóIldikó HorváthNoémi KovácsBernadett MartineczÁdám DénesDaniel SeifertRalf BergmannOndřej LebedaZoltán VargaZoltán KaletaKrisztián SzigetiDomokos MáthéPublished in: Molecular imaging and biology (2019)
Our results suggest that [125I]CLINME and [99mTc]HMPAO SPECT can be used to detect microglia activation and brain hypoperfusion, respectively, in the early phase (4 h post injection) of systemic inflammation. We suspect that the enhancement of [18F]FDG and [125I]iomazenil uptake in the LPS-treated group does not necessarily reflect neural hypermetabolism and the lack of neuronal damage. They are most likely caused by processes emerging during neuroinflammation, e.g., microglia activation and/or immune cell infiltration.
Keyphrases
- cerebral ischemia
- inflammatory response
- resting state
- white matter
- pet ct
- lipopolysaccharide induced
- cognitive impairment
- neuropathic pain
- functional connectivity
- high resolution
- subarachnoid hemorrhage
- intensive care unit
- oxidative stress
- acute kidney injury
- early onset
- blood brain barrier
- positron emission tomography
- brain injury
- pet imaging
- septic shock
- multiple sclerosis
- spinal cord injury
- fluorescence imaging