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Shared Genetic Architecture between Muscle and Bone: Identification and Functional Implications of EPDR1 , PKDCC , and SPTBN1 .

Jongyun JungQing Wu
Published in: bioRxiv : the preprint server for biology (2023)
- which are highly active in muscle tissue and influence bone health. These discoveries offer fresh insights into the interconnected genetic makeup of bone and muscle. Our work not only uncovers potential targets for therapeutic strategies to enhance bone and muscle strength but also provides a blueprint for identifying shared genetic structures across multiple tissues. This research represents a crucial step forward in our understanding of the interplay between our muscles and bones at a genetic level.
Keyphrases
  • bone mineral density
  • genome wide
  • skeletal muscle
  • soft tissue
  • bone loss
  • copy number
  • healthcare
  • bone regeneration
  • postmenopausal women
  • gene expression
  • mental health
  • public health
  • risk assessment
  • social media