Ventilatory Drive Withdrawal Rather Than Reduced Genioglossus Compensation as a Mechanism of Obstructive Sleep Apnea in REM.

Ludovico MessineoDanny J EckertLuigi Taranto-MontemurroDaniel VenaAli AzarbarzinLauren B HessNicole CalianeseDavid P WhiteAndrew WellmanLaura GellScott A Sands

Published in: American journal of respiratory and critical care medicine (2021)

In OSA patients, the pharyngeal compromise characteristic of REM appears to be explained by ventilatory drive withdrawal rather than preferential decrements in muscle activity or responsiveness. Preventing drive withdrawal may be the leading target for REM OSA.

Keyphrases

obstructive sleep apnea
positive airway pressure
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
sleep apnea