Promoter hypermethylation of RARB and GSTP1 genes in plasma cell-free DNA as breast cancer biomarkers in Peruvian women.
Pierina DanosStefano Giannoni-LuzaAlexis Germán Murillo CarrascoOscar AcostaMaria Luisa Guevara-FujitaJosé Manuel Cotrina ConchaHenry Guerra MillerJoseph Pinto OblitasAlfredo Aguilar CartagenaJhahaira Araujo SoriaRicardo M FujitaJosé Luis Buleje SonoPublished in: Molecular genetics & genomic medicine (2023)
Promoter hypermethylation of RARB + GSTP1 genes is associated with breast cancer, older age, and postmenopausal Peruvian patients. The methylated promoter of the RARB + GSTP1 genes needs further validation to be used as a biomarker for liquid biopsy and as a recommendation criterion for additional tests in asymptomatic women younger than 50 years.
Keyphrases
- dna methylation
- genome wide
- breast cancer risk
- transcription factor
- end stage renal disease
- polycystic ovary syndrome
- gene expression
- genome wide identification
- bioinformatics analysis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- physical activity
- prognostic factors
- pregnancy outcomes
- peritoneal dialysis
- type diabetes
- ionic liquid
- metabolic syndrome
- bone mineral density
- insulin resistance
- ultrasound guided
- adipose tissue
- postmenopausal women
- skeletal muscle
- community dwelling