Interaction between angiotensin-converting enzyme gene rs4343 polymorphism, environment factors, and angiotensin II level on susceptibility to knee osteoarthritis.
Basma Mohammed Mohammed Ali ElnaggarNashwa Mohamed Abd ElbakyEman Salah AlbeltagyHala Mohamed El ZomorPublished in: Reumatologia clinica (2024)
The investigated polymorphism in the ACE gene rs4343 may reflect the risk and severity of knee OA in the Egyptian population, particularly with the GG genotype. The interaction between ACE gene rs4343 polymorphism and obesity further increased the risk of knee OA. Moreover, the higher angiotensin II level may be involved in the pathogenesis of knee OA.
Keyphrases
- knee osteoarthritis
- angiotensin ii
- angiotensin converting enzyme
- vascular smooth muscle cells
- copy number
- genome wide
- genome wide identification
- total knee arthroplasty
- metabolic syndrome
- insulin resistance
- weight loss
- type diabetes
- weight gain
- gene expression
- mass spectrometry
- high resolution
- adipose tissue
- body mass index
- transcription factor
- genome wide analysis
- single molecule