Lipolysis and gestational diabetes mellitus onset: a case-cohort genome-wide association study in Chinese.
Miao ZhangQing LiKai-Lin WangYao DongYu-Tong MuYan-Min CaoJin LiuZi-Heng LiHui-Lu CuiHai-Yan LiuAn-Qun HuYing-Jie ZhengPublished in: Journal of translational medicine (2023)
Genes related to lipolysis, redox reaction, and proliferation of islet β-cells are associated with GDM in Chinese women. Energy metabolism, particularly lipolysis, may play an important role in GDM aetiology and pathology, which needs further molecular studies to verify.
Keyphrases
- adipose tissue
- genome wide association study
- induced apoptosis
- pregnancy outcomes
- cell cycle arrest
- signaling pathway
- polycystic ovary syndrome
- pregnant women
- insulin resistance
- genome wide
- endoplasmic reticulum stress
- cell death
- metabolic syndrome
- type diabetes
- electron transfer
- case control
- single molecule
- dna methylation
- pi k akt
- breast cancer risk