KPR-2579, a novel TRPM8 antagonist, inhibits acetic acid-induced bladder afferent hyperactivity in rats.

Naoki AizawaYoshikazu FujimoriJun-Ichi KobayashiOsamu NakanishiHideaki HirasawaHaruki KumeYukio HommaYasuhiko Igawa

Published in: Neurourology and urodynamics (2018)

The present results suggest that TRPM8 channels play a role in the AA-induced pathological activation of mechanosensitive bladder C fibers in rats. KRP-2579 may be a promising drug for hypersensitive bladder disorders.

Keyphrases

spinal cord injury
urinary tract
drug induced
high glucose
diabetic rats
emergency department
electronic health record