Exosomal microRNAs: novel players in cervical cancer.
Javid Sadri NahandNoushin Rezaei VandchaliHassan DarabiMohammad DoroudianHamid Reza BanafsheMohsen MoghoofeiFarhad BabaeiArash SalmaninejadHamed MirzaeiPublished in: Epigenomics (2020)
Cervical cancer ranks fourth for both mortality and morbidity in women globally. Exosomes are considered as extracellular vesicles, secreted continuously by many cells with a size range from 30 to 150 nm. Exosomes can encapsulate microRNAs (miRNAs) and release them for cellular communications. This exosome-induced miRNA transfer is a novel strategy for genetic exchange among cells. This trafficking modality affects many pathological as well as physiological conditions. Moreover, exosomes can protect the miRNAs against harsh environments and keep them very stable. Given that a variety of exosomal miRNAs derived from cervical cancer cells can be targeted to recipient cells and contribute to tumorgenesis, it has been documented that exosomal miRNAs could be applied as diagnostic and therapeutic biomarkers in the treatment of cervical cancer. Herein, we summarize the pathologic and diagnostic roles of exosomal miRNAs in the cervical cancer. Moreover, we highlight the roles of exosomal miRNAs in other cancers.
Keyphrases
- induced apoptosis
- cell cycle arrest
- mesenchymal stem cells
- stem cells
- endoplasmic reticulum stress
- type diabetes
- oxidative stress
- signaling pathway
- gene expression
- photodynamic therapy
- adipose tissue
- young adults
- radiation therapy
- neoadjuvant chemotherapy
- insulin resistance
- skeletal muscle
- cell proliferation
- endothelial cells
- dna methylation
- replacement therapy