Linezolid toxicity in patients with drug-resistant tuberculosis: a prospective cohort study.
Sean WassermanJames C M BrustMahmoud Tareq AbdelwahabFrancesca LittlePaolo DentiLubbe WiesnerNeel R GandhiGraeme MeintjesGary MaartensPublished in: The Journal of antimicrobial chemotherapy (2022)
Permanent discontinuation of linezolid was common, but linezolid-containing therapy was associated with average improvement in toxicity measures. HIV co-infection was not independently associated with linezolid toxicity. Linezolid trough concentration of 2.5 mg/L should be evaluated as a target for therapeutic drug monitoring.
Keyphrases
- drug resistant
- methicillin resistant staphylococcus aureus
- multidrug resistant
- oxidative stress
- acinetobacter baumannii
- hiv aids
- antiretroviral therapy
- hiv infected
- hepatitis c virus
- human immunodeficiency virus
- staphylococcus aureus
- mycobacterium tuberculosis
- hiv positive
- hiv testing
- oxide nanoparticles
- bone marrow
- men who have sex with men
- south africa
- pulmonary tuberculosis
- adverse drug
- smoking cessation