The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3.

Tao ChenWen-Bo LiuXiao QianKe-Liang XieYu-Hai Wang

Published in: CNS neuroscience & therapeutics (2021)

Our results indicate that the noncompetitive AMPAR antagonist perampanel protects the NVU system and reduces brain damage after TBI via activating the Sirt3 cascades.

Keyphrases

oxidative stress
traumatic brain injury
spinal cord injury
ischemia reperfusion injury
signaling pathway
white matter
resting state
cerebral ischemia
multiple sclerosis
blood brain barrier