Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper.
M H Mohamed ShamjiJ H KappenM AkdisErika Jensen-JarolimE F KnolJ Kleine-TebbeB BohleA M ChakerS J TillR ValentaL K PoulsenM A CalderonP DemolyOliver PfaarL JacobsenS R DurhamC B Schmidt-WeberPublished in: Allergy (2017)
It is recommended to explore the use of allergen-specific IgG4 as a biomarker for compliance. sIgE/tIgE and IgE-FAB are considered as potential surrogate candidate biomarkers. Cytokine/chemokines and cellular reponses provided insight into the mechanisms of AIT. More studies for confirmation and interpretation of the possible association with the clinical response to AIT are needed.