MALAT1 as a Regulator of the Androgen-Dependent Choline Kinase A Gene in the Metabolic Rewiring of Prostate Cancer.

Sara De Martino Egidio IorioChiara CencioniAurora AielloFrancesco SpallottaMattea ChiricoMaria Elena PisanuClaudio GrassiAlfredo PontecorviCarlo GaetanoSimona NanniAntonella Farsetti

Published in: Cancers (2022)

These findings support the role of MALAT1 as a CHKA activator through putative association with the liganded or unliganded AR, unveiling its targeting as a therapeutic option from a metabolic rewiring perspective.

Keyphrases

prostate cancer
radical prostatectomy
genome wide
cancer therapy
transcription factor
nuclear factor
tyrosine kinase
gene expression
immune response
genome wide identification
dna methylation
drug delivery