The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer.
Martin WidschwendterMichal ZikanBenjamin WahlHarri LempiäinenTobias PaprotkaIona EvansAllison JonesShohreh GhazaliDaniel ReiselJohannes EichnerTamas RujanZhen YangAndrew E TeschendorffAndy RyanDavid CibulaUsha MenonTimo WittenbergerPublished in: Genome medicine (2017)
Our data suggest that DNA methylation patterns in cell-free DNA have the potential to detect a proportion of OCs up to two years in advance of diagnosis and may potentially guide personalized treatment. The prospective use of novel collection vials, which stabilize blood cells and reduce background DNA contamination in serum/plasma samples, will facilitate clinical implementation of liquid biopsy analyses.
Keyphrases
- circulating tumor
- dna methylation
- cell free
- circulating tumor cells
- induced apoptosis
- genome wide
- human health
- gene expression
- primary care
- risk assessment
- healthcare
- cell cycle arrest
- big data
- single molecule
- oxidative stress
- signaling pathway
- ultrasound guided
- health risk
- endoplasmic reticulum stress
- climate change
- machine learning
- artificial intelligence
- heavy metals
- smoking cessation
- data analysis