Viral-mediated inflammation by Poly I:C induces the chemokine CCL5 in NK cells and its receptors CCR1 and CCR5 in microglia in the neonatal rat cerebellum.

Miguel Perez-PouchoulenAmanda S HolleyErin L ReinlJonathan W VanRyzinAmir MehrabaniChristie DionisosMuhammed MirzaMargaret M McCarthy

Published in: NeuroImmune pharmacology and therapeutics (2024)

Our findings suggest an important role for CCL5 and other immune cells in mediating inflammation in the developing cerebellum that potentially impact the maturation of cerebellar neurons during a critical period of development.

Keyphrases

oxidative stress
nk cells
dendritic cells
liver fibrosis
regulatory t cells
liver injury
sars cov
spinal cord
inflammatory response
drug induced
neuropathic pain
spinal cord injury
immune response