Aldosterone Induces the Proliferation of Renal Tubular Epithelial Cells In Vivo but Not In Vitro.

Juan HaoLingjin LiuZiqian LiuGege ChenYunzhao XiongXiangting WangXuelian Ma Qingyou Xu

Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2021)

Aldosterone perfusion can induce proliferation of mouse kidney cells in vivo, and eplerenone can inhibit this change, but aldosterone stimulates HK2 cells and mDCT in vitro without causing their proliferation.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
angiotensin ii
endoplasmic reticulum stress
cell death
computed tomography
magnetic resonance