A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing.
Chien-Wei WangSimon D WeaverNicha BoonpattrawongNaviya Schuster-LittleManish Suresh PatankarRebecca J WhelanPublished in: Cancer research communications (2024)
Despite its crucial role in clinical management of ovarian cancer, the exact molecular sequence and structure of the biomarker, CA125, are not defined. Here, we combine long-read sequencing, mass spectrometry, and in silico modeling to provide the foundational dataset for a more complete characterization of the CA125 epitope.