Bone health in young adults with type 1 diabetes and progressive eGFR decline.
Funmbi BabalolaJill HamiltonMichael ZappitelliYesmino EliaJacqueline CurtisRahim MoineddinFarid H MahmudPublished in: Clinical diabetes and endocrinology (2024)
Mild increase in cortical porosity diameter was found in youth with T1D and eGFR decline, however, overall measures of bone microarchitecture on HR-pQCT were similar between both groups and there were no statistically significant changes in bone biomarkers. Hence, skeletal impairments were limited in youth with different eGFR trajectories near peak bone mass. Longitudinal HR-pQCT studies are needed to further understand the impact of eGFR decline on bone microarchitecture. Optimal glycemic control, normal BMI and vitamin D status were supported by this study as important markers for good bone health.
Keyphrases
- bone mineral density
- small cell lung cancer
- young adults
- epidermal growth factor receptor
- mental health
- soft tissue
- tyrosine kinase
- bone loss
- healthcare
- glycemic control
- bone regeneration
- public health
- physical activity
- multiple sclerosis
- postmenopausal women
- body mass index
- depressive symptoms
- adipose tissue
- metabolic syndrome
- blood glucose
- skeletal muscle