Slight brightness and osteosclerotic changes of bones on plain X-ray could be clues to the diagnosis of disseminated carcinomatosis of bone marrow.

Clinicians should be alert to the presence of slight brightness and osteosclerotic changes of bones on plain X-rays, especially in patients without a history of gastric, colon, breast, lung, or prostate cancers, which could lead to the diagnosis of disseminated carcinomatosis of bone marrow.