Clinical and genetic determinants of ovarian metastases from colorectal cancer.
Karuna GaneshRonak H ShahEfsevia VakianiGarrett M NashHugh P SkottoweRona YaegerAndrea CercekAnne LincolnChristina TranNeil H SegalDiane L ReidyAnna VargheseAndrew S EpsteinYukio SonodaDennis ChiJose GuillemLarissa TemplePhilip PatyJaclyn HechtmanJinru ShiaMartin WeiserJulio Garcia AguilarNancy KemenyMichael F BergerLeonard SaltzZsofia K StadlerPublished in: Cancer (2016)
Loss-of-function alterations in SMAD4 are frequent and predictive of worse survival in patients with OM-CRC. Similar to oligometastatic CRC to the lung or liver, surgical resection of OM-CRC is associated with a better outcome only if all macroscopic metastatic disease is resected. Cancer 2017;123:1134-1143. © 2016 American Cancer Society.